Hepatitis B Virus

Studies from Technical University of Munich provide new data on hepatitis B virus

Published in Hepatitis Weekly, January 25th, 2010

"With about 350 million virus carriers, hepatitis B virus (HBV) infection remains a major health problem. HBV is a noncytopathic virus causing persistent infection, but it is still unknown whether host recognition of HBV may activate an innate immune response," investigators in Munich, Germany report.

"We describe that upon infection of primary human liver cells, HBV is recognized by nonparenchymal cells of the liver, mainly by liver macrophages (Kupffer cells), although they are not infected. Within 3 hours, this recognition leads to the activation of nuclear factor kappa B (NF-kappa B) and subsequently to the release of interleukin-6 (IL-6) and other proinflammatory...

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Source: Hepatitis Weekly (2010-01-25)

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