Hepatitis C Virus

Reports by R.E. Lanford and co-researchers describe recent advances in hepatitis C virus

Published in Hepatitis Weekly, February 8th, 2010

"The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for antiviral intervention has not been assessed," researchers in Denmark report.

"We found that treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)-modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia, with no evidence of viral resistance or side effects in the treated animals. Furthermore, transcriptome and histological analyses of liver biopsies demonstrated derepression of target mRNAs with miR-122 seed sites, down-regulation of...

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Source: Hepatitis Weekly (2010-02-08)

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