Hepatitis B Virus

New findings from E. Matthes and co-authors describe advances in hepatitis B virus

Published in Hepatitis Weekly, February 15th, 2010

According to a study from Berlin, Germany, "beta-L-2',3'-Didehydro-2',3'-dideoxy-N-4-hydroxycytidine (L-Hyd4C) was demonstrated to be an effective and highly selective inhibitor of hepatitis B virus (HBV) replication in HepG2.2.15 cells (50% effective dose [ED50] = 0.03 mu M; 50% cytotoxic dose [CD50] = 2,500 mc M). In the present study, we investigated the intracellular pharmacology of tritiated L-Hyd4C in HepG2 cells."

"L-[H-3] Hyd4C was shown to be phosphorylated extensively and rapidly to the 5'-mono-, 5'-di-, and 5'-triphosphate derivatives. Other metabolites deriving from a reduction or removal of the NHOH group of L-Hyd4C could not be detected, although both...

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Source: Hepatitis Weekly (2010-02-15)

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