Hepatitis C Virus
Studies conducted at New York Medical College on hepatitis C virus recently published
Published in Hepatitis Weekly, April 5th, 2010
Scientists discuss in 'Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor' new findings in hepatitis C virus. "This study examines the effects of 1-N,4-N-bis[4-(1H-benzimidazol-2-yl)phenyl]benzene-1,4-dicarboxamide ((BIP)(2)B) on the NS3 helicase encoded by the hepatitis C virus (HCV). Molecular beacon-based helicase assays were used to show that (BIP)(2)B inhibits the ability of HCV helicase to separate a variety of RNA and DNA duplexes with half-maximal inhibitory concentrations ranging from 0.7 to 5 microM, depending on the nature of the substrate," scientists in the United States report.
"In single turnover assays, (BIP)(2)B...
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Source: Hepatitis Weekly (2010-04-05)
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