Hepatitis E Virus

Studies by Y.A. Karpe and co-authors describe new findings in hepatitis E virus

Published in Hepatitis Weekly, May 3rd, 2010

According to recent research from Pune, India, "Hepatitis E virus (HEV) is a causative agent of acute hepatitis, and it is the sole member of the genus Hepevirus in the family Hepeviridae. The open reading frame 1 (ORF1) protein of HEV encodes nonstructural polyprotein with putative domains for methyltransferase, cysteine protease, helicase and RNA-dependent RNA polymerase."

"It is not yet known whether ORF1 functions as a single protein with multiple domains or is processed to form separate functional units. On the basis of amino acid conserved motifs, HEV helicase has been grouped into helicase superfamily 1 (SF-1). In order to examine the RNA helicase activity of the...

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Source: Hepatitis Weekly (2010-05-03)

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