Clinical Trial Research

Data from M.L. Shiffman et al provide new insights into clinical trial research

Published in Hepatitis Weekly, May 17th, 2010

According to recent research from the United States, "Elevated serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) reflect hepatocellular injury in patients with chronic hepatitis C virus (HCV). Increased apoptosis and activated caspases are present in these patients."

"PF-03491390 inhibits multiple caspases and lowers serum AST and ALT levels in patients with chronic liver diseases. To determine if treatment with an oral pancaspase inhibitor could reduce serum AST and ALT in patients with HCV. Double-blind, randomized, placebo-controlled, parallel-dose study in 204 patients treated with placebo or PF-03491390 (5, 25 or 50 mg) orally...

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Source: Hepatitis Weekly (2010-05-17)

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