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Hepatitis C Virus

New research on hepatitis C virus from D. Bankwitz and co-authors summarized

Published in Hepatitis Weekly, May 24th, 2010

Fresh data on hepatitis C virus are presented in the report 'Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes.' According to a study from Hannover, Germany, "The variability of the hepatitis C virus (HCV), which likely contributes to immune escape, is most pronounced in hypervariable region 1 (HVR1) of viral envelope protein 2. This domain is the target for neutralizing antibodies, and its deletion attenuates replication in vivo."

"Here we characterized the relevance of HVR1 for virus replication in vitro using cell culture-derived HCV. We show that HVR1 is dispensable...

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