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Hepatitis C Virus

Research reports on hepatitis C virus from University of Connecticut, Health Center provide new insights

Published in Hepatitis Weekly, May 24th, 2010

Investigators publish new data in the report 'Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics.' In this recent study, researchers in the United States conducted a study "To examine the effect of hepatitis C virus (HCV) structural mimics of regulatory regions of the genome on HCV replication. HCV RNA structural mimics were constructed and tested in a HCV genotype 1b aBB7 replicon, and a Japanese fulminant hepatitis-1 (JFH-1) HCV genotype 2a infection model."

"All sequences were computer-predicted to adopt stem-loop structures identical to the corresponding elements in full-length viral RNA. Huh7.5 cells bearing the BB7 replicon or...

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