Gastroenterology

Findings from Pennsylvania State University, Department of Chemistry provide new insights into gastroenterology

Published in Hepatitis Weekly, July 12th, 2010

Data detailed in 'The human HDV-like CPEB3 ribozyme is intrinsically fast-reacting' have been presented. According to a study from the United States, "Self-cleaving RNAs have recently been identified in mammalian genomes. A small ribozyme related in structure to the hepatitis delta virus (HDV) ribozyme occurs in a number of mammals, including chimpanzees and humans, within an intron of the CPEB3 gene."

"The catalytic mechanisms for the CPEB3 and HDV ribozymes appear to be similar, generating cleavage products with 5'-hydroxyl and 2',3'-cyclic phosphate termini; nonetheless, the cleavage rate reported for the CPEB3 ribozyme is more than 6000-fold slower than for the...

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Source: Hepatitis Weekly (2010-07-12)

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