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Transcription Factors

Data from Catholic University of Louvain provide new insights into transcription factors

Published in Hepatitis Weekly, July 26th, 2010

According to a study from Brussels, Belgium, "Conflicting observations exist concerning the role of nuclear factor kappa B (NF kappa B) in alcoholic liver disease (ALD) in animal models. To date no studies have examined this aspect in human liver tissue."

"We here assessed cytokines and toll-like receptors (TLRs) expressions in conjunction with NF kappa B activation in non-active end-stage human ALD compared with normal livers and hepatitis C virus (HCV) related end-stage disease. mRNA and protein expression were examined by quantitative PCR and Western blotting, DNA-binding by electrophoretic mobility shift assays and NF kappa B sub-cellular localization by...

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