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Nucleocapsid

Data on nucleocapsid discussed by investigators at Kyoto University, Institute for Virus Research

Published in Hepatitis Weekly, September 13th, 2010

Research findings, 'A disulfide-bonded dimer of the core protein of hepatitis C virus is important for virus-like particle production,' are discussed in a new report. According to a study from Kyoto, Japan, "Hepatitis C virus (HCV) core protein forms the nucleocapsid of the HCV particle. Although many functions of core protein have been reported, how the HCV particle is assembled is not well understood."

"Here we show that the nucleocapsid-like particle of HCV is composed of a disulfide-bonded core protein complex (dbc-complex). We also found that the disulfide-bonded dimer of the core protein (dbd-core) is formed at the endoplasmic reticulum (ER), where the core...

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