Hepatitis C Virus

Findings from F. Hoffmann-LaRoche Ltd. provide new insights into hepatitis C virus

Published in Hepatitis Weekly, October 4th, 2010

Data detailed in 'Isolation and identification of ester impurities in RG7128, an HCV polymerase inhibitor' have been presented. According to a study from the United States, "RG7128 is a di-ester prodrug of a cytidine analog for the treatment of hepatitis C virus (HCV) infection. The structures of nine low level impurities (0.05-0.10%) in RG7128 drug substance were elucidated."

"The majority of the impurities were formed during the synthesis of the prodrug from the parent drug. Structural elucidations of the impurities were achieved either by enrichment of the impurities using preparative chromatography followed by spectroscopic techniques or by confirmation with a...

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Source: Hepatitis Weekly (2010-10-04)

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