Hepatitis C Virus
Data on hepatitis C virus discussed by researchers at Cleveland Clinic, Department of Cancer Biology
Published in Hepatitis Weekly, November 8th, 2010
A new study, 'RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP,' is now available. According to a study from the United States, "Triggering and propagating an intracellular innate immune response is essential for control of viral infections. RNase L is a host endoribonuclease and a pivotal component of innate immunity that cleaves viral and cellular RNA within single-stranded loops releasing small structured RNAs with 5'-hydroxyl (5'-OH) and 3'-monophosphoryl (3'-p) groups."
"In 2007, we reported that RNase L cleaves self RNA to produce small RNAs that function as pathogen-associated molecular patterns (PAMPs). However, the precise sequence and...
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Source: Hepatitis Weekly (2010-11-08)
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