Hepatitis C Virus
Research on hepatitis C virus reported by scientists at Chinese Academy of Sciences
Published in Hepatitis Weekly, November 15th, 2010
A report, 'Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner,' is newly published data in The Journal of Virology. According to recent research from Shanghai, People's Republic of China, "Hepatitis C virus (HCV) replication and infection depend on the lipid components of the cell, and replication is inhibited by inhibitors of sphingomyelin biosynthesis. We found that sphingomyelin bound to and activated genotype 1b RNA-dependent RNA polymerase (RdRp) by enhancing its template binding activity."
"Sphingomyelin also bound to 1a and JFH1 (genotype 2a) RdRps but did not activate them. Sphingomyelin did not bind to or activate J6CF...
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Source: Hepatitis Weekly (2010-11-15)
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