Hepatitis C Virus
New Findings Reported from Erasmus Medical Center Describe Advances in Hepatitis C Virus
Published in Hepatitis Weekly, May 30th, 2011
2011 MAY 30 -- "RNA interference (RNAi) is widely used as a screening tool for the identification of host genes involved in viral infection. Due to the limitation of raw small interfering RNA (siRNA), we tested two commonly used short hairpin RNA (shRNA) lentiviral libraries to identify host factors involved in hepatitis C virus (HCV) infection," scientists writing in the journal Febs Letters report.
"It was found that these shRNA library vectors caused non-specific disturbance of HCV replication that was not due to toxicity or interferon response, but related to the high shRNA levels disturbing the endogenous microRNA biogenesis. The high shRNA...
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Source: Hepatitis Weekly (2011-05-30)
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