Findings from University of Freiburg in Hepatitis C Virus Reported

2011 SEP 5 -- New investigation results, "Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase," are detailed in a study published in The Journal of Virology. According to the authors of a study from Freiburg, Germany, "Hepatitis C virus (HCV) nonstructural protein 5B (NS5B), the viral RNA-dependent RNA polymerase (RdRp), is a tail-anchored protein with a highly conserved C-terminal transmembrane domain (TMD) that is required for the assembly of a functional replication complex. Here, we report that the TMD of the HCV RdRp can be functionally replaced by a newly identified...

Want to see the full article?

• Purchase this article for only $3.00