Immunologic Receptors

Researchers at Stanford University Release New Data on Immunologic Receptors

Published in Hepatitis Weekly, September 12th, 2011

2011 SEP 12 -- "CD81 (TAPA-1) is a member of the widely expressed and evolutionary conserved tetraspanin family that forms complexes with a variety of other cell surface receptors and facilitates hepatitis C virus entry. Here, we show that CD81 is specifically required for the formation of lamellipodia in migrating dendritic cells (DCs)," scientists in Stanford, California report.

"Mouse CD81(-/-) DCs, or murine and human CD81 RNA interference knockdown DCs lacked the ability to form actin protrusions, thereby impairing their motility dramatically. Moreover, we observed a selective loss of Rac1 activity in the absence of CD81, the latter of which is...

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Source: Hepatitis Weekly (2011-09-12)

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