Hepatitis C Virus

New Hepatitis C Virus Research from ICGEB Described

Published in Hepatitis Weekly, October 17th, 2011

2011 OCT 17 -- "Several clinical observations point to an intricate crosstalk between iron (Fe) metabolism and chronic hepatitis C virus (HCV) infection. In this study, we wanted to investigate the molecular control that Fe levels exert on HCV replication at the hepatocyte level," scientists writing in the Journal of General Virology report.

"In keeping with previous observations we confirmed that supra-physiological intracellular Fe induced by haemin treatment down-modulated HCV replication from subgenomic replicons. We also found that RNAi-mediated knockdown of the key Fe modulator hepcidin increased intracellular ferritin and inhibited HCV...

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Source: Hepatitis Weekly (2011-10-17)

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