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Scientists at Tulane University Release New Data on Virology

Published in Hepatitis Weekly, December 12th, 2011

2011 DEC 12 -- Research findings, "Mechanism of HCV's resistance to IFN-a in cell culture involves expression of functional IFN-a receptor 1," are discussed in a new report. According to the authors of a study from New Orleans, Louisiana, "The mechanisms underlying the Hepatitis C virus (HCV) resistance to interferon alpha (IFN-a) are not fully understood. We used IFN-a resistant HCV replicon cell lines and an infectious HCV cell culture system to elucidate the mechanisms of IFN-a resistance in cell culture."

"The IFN-a resistance mechanism of the replicon cells were addressed by a complementation study that utilized the full-length plasmid clones of IFN-a...

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