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Transplantation

Research from University of Basel in transplantation provides new insights

Published in Hospital Business Week, October 28th, 2007

"'Background. Tubulointerstitial injury due to rejection leads to tubular atrophy (TA)/interstitial fibrosis (IF) followed by deterioration of allograft function," scientists writing in the journal Transplantation report.

"This study investigated whether urinary tubular injury biomarkers can detect subclinical tubulitis found in protocol biopsies allowing for a noninvasive screening procedure. Four rigidly defined groups (stable transplants with normal tubular histology [n = 24], stable transplants with subclinical tubulitis [n = 38], patients with clinical tubulitis Ia/Ib [n = 18), and patients with other clinical tubular pathologies [n = 20]) were compared for...

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