Investigative Dermatology

Research results from Cantonal Hospital update understanding of investigative dermatology

Published in Hospital Business Week, December 16th, 2007

According to recent research from Geneva, Switzerland, "Claudin- 1 is a critical structural component of tight junctions that have an important role in adhesive properties, barrier function, and paracellular transport of epithelia and other nonhematopoietic tissues. We found claudin-1 in murine CD207 + Langerhans cells ( LC) residing in epidermis."

"Claudin- 1 was not detected in other skin dendritic cells ( DC). LC expressed claudin- 1 in steady state and inflamed skin. Claudin- 1 was demonstrated further in lymph node LC under steady state and inflammatory conditions, including after direct tracking with tetramethylrhodamine- isothiocyanate ( TRITC). All subsets of...

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Source: Hospital Business Week (2007-12-16)

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