Transplantation

Research reports from Zhongshan University provide new insights into transplantation

Published in Hospital Business Week, December 23rd, 2007

According to a study from Guangzhou, People's Republic of China, "Many hematological diseases require long-term transfusion support, which causes production of donor-reactive antibodies in sensitized recipients. Sensitized patients are at an increased risk for graft rejection when they undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT)."

"Here, we established a highly sensitized murine model to investigate the mechanism of donor graft rejection. After BALB/c mice were repeatedly transfused with allogeneic spleen cells from C57BL/6 mice, there was a significant increase in complement-dependent cytotoxicity in the serum of sensitized mice. For...

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Source: Hospital Business Week (2007-12-23)

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