Gene Therapy

Recent findings from University of Oxford highlight research in gene therapy

Published in Hospital Business Week, December 23rd, 2007

"Background RNA-based gene silencing is potentially a powerful therapeutic strategy. Catalytic 10-23 DNAzymes bind to target RNA by complimentary sequence arms on a Watson-Crick basis and thus can be targeted to effectively cleave specific mRNA species," investigators in Oxford, the United Kingdom report.

"However, for in vivo applications it is necessary to stabilise DNAzymes against nucleolytic attack. Chemical modifications can be introduced into the binding arms to increase stability but these may alter catalytic activity and in some cases increase cell toxicity. Methods We designed novel 10-23 DNAzyme structures that incorporate stem-loop hairpins at either end on...

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Source: Hospital Business Week (2007-12-23)

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