Published in Hospital Business Week, May 25th, 2008
"In this system, the transgene expression was driven by an endogenous RNA polymerase I (Pot I) promoter after being integrated into the ribosomal DNA (rDNA) locus. Human coagulation factor IX coding sequence (FIX), with an internal ribosome entry sites element at its leader region, was targeted into the 18S rDNA locus via homologous recombination. FIX protein expression, which was under the...
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