Breast Cancer
Scientists at University of London, Imperial College target breast cancer
Published in Hospital Business Week, June 22nd, 2008
"Proteasome inhibitors are a novel class of compounds entering clinical trials as a method to increase tumour sensitivity to standard chemotherapy. This phase I/II trial was carried out to evaluate the combination of capecitabine and the proteasome inhibitor bortezomib in anthracycline and/or taxane-pretreated patients with metastatic breast cancer," researchers in London, the United Kingdom report.
"A total of 35 patients were treated with bortezomib (1.0-1.3 mg/m(2) on days 1, 4, 8 and 11) and capecitabine (1500-2500 mg/m(2) on days 1-14) in 3-week intervals for up to eight cycles. The maximum tolerated doses (MTDs) were bortezomib 1.3 mg/m(2) and capecitabine 2500...
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