Harvard Medical School

Simple chemical procedure augments therapeutic potential of stem cells

Published in Hospital Business Week, November 23rd, 2008

Adult stem cells resemble couch potatoes if they hang out and divide in a dish for too long. They get fat and lose key surface proteins, which interferes with their movement and reduces their therapeutic potential. Now, via a simple chemical procedure, researchers have found a way to get these cells off the couch and over to their therapeutic target.

To do this, they simply added a molecule called SLeX to the surface of the cells. The procedure took just 45 minutes and restored an important biological function.

"Delivery remains one of the biggest hurdles to stem cell therapy," explains senior author Jeffrey Karp, an instructor at the Harvard-MIT...

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Source: Hospital Business Week (2008-11-23)

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