Life Sciences
Studies from Harvard University, Department of Molecular Biology further understanding of life sciences
Published in Hospital Business Week, December 14th, 2008
Researchers detail in 'Characterization of two Mst1-deficient mouse models,' new data in life sciences. "Mammalian sterile 20-like kinase 1 (Mst1) is a ubiquitously expressed serine/threonine kinase belonging to the family of Sterile 20-like kinases. MST1 has been inferred to play important roles in apoptosis and in the inhibition of proliferation in mammalian cells," scientists in the United States report.
"Here, we describe the genetic characterization of Mst1-deficient mice produced by two distinct gene-trap insertions. Animals generated from clone RRT293 exhibit transmission ratio distortion favoring the mutated allele which is amplified with each generation....
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