Prostate Cancer

Study data from Fourth Military Medical University provide new insights into prostate cancer

Published in Hospital Business Week, December 21st, 2008

"Heparanase is an endoglycosidase that plays an important role in angiogenesis and metastasis of cancer. Herein we evaluate the effect of heparanase overexpression on invasiveness and bone destruction in prostate cancer bone metastases," investigators in Xian, People's Republic of China report.

"The human prostate cancer cell line PC-3 was stably transfected with a plasmid containing the cDNA for human heparanase or with the vector alone as a control. Overexpression of heparanase did not affect the growth of PC-3 cells, but did promote invasiveness of the cells in an in vitro assay. Both cell types were injected into the tibias of nude mice. Four weeks later, the mice...

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Source: Hospital Business Week (2008-12-21)

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