Clinical Cancer Research
Studies from F.H. Chen et al add new findings in the area of clinical cancer research
Published in Hospital Business Week, April 26th, 2009
In this recently published study, investigators in Taiwan conducted a study "To investigate how single or fractionated doses of radiation change the microenvironment in transgenic adenocarcinoma of the mouse prostate (TRAMP)-C1 tumors with respect to vascularity, hypoxia, and macrophage infiltrates. Murine prostate TRAMP-C1 tumors were grown in C57BL/6J mice to 4 mm tumor diameter and were irradiated with either 25 Gy in a single dose or 60 Gy in 15 fractions."
"Changes in vascularity, hypoxia, and macrophage infiltrates were assessed by immunohistochemistry and molecular assays. Tumor growth was delayed for 1 week after both radiation schedules. Tumor microvascular...
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