Columbus Children's Hospital

Technique efficiently delivers gene therapy to soft-tissue tumors

Published in Hospital Law Weekly, May 27th, 2004

Researchers at the Columbus Children's Research Institute (CCRI), on the campus of the Columbus Children's Hospital, have found a way to efficiently genetically modify MSCs using a modified adeno-associated virus (AAV) vector system and deliver therapeutic genes to the site of a tumor.

The researchers are using new research and technology that shows bone-marrow-derived mesenchymal stem cells (MSCs) will engraft at the site of a tumor and contribute to the growth of stromal fibroblasts (the healthy tissue surrounding a tumor. The procedure proved to be over a thousand times more efficient than other vector systems. The research, the first of its kind, was presented at...

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Source: Hospital Law Weekly (2004-05-27)

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