Hospital Universitario Central de Asturias, Oviedo
KIR3DL1 and HLA-B*57 supertype allele interactions influence HIV-1 progression
Published in Hospital Law Weekly, September 29th, 2005
According to recent research published in the journal Human Immunology, "KIR and HLA loci are both highly polymorphic, and some HLA class 1 products bind and trigger cell-surface receptors specified by KIR genes. We examined whether KIR genes act in concert with HLA-B locus to control HIV-1 infection in a sample of Zambian patients.
"DNA samples from 88 Zambian patients with HIV-1 were examined. Patients were classified as either slow progressors (SP; n=54) or rapid progressors (RP; n=34) to AIDS. All were typed for HLA-B and KIR genes."
"Our...
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Source: Hospital Law Weekly (2005-09-29)
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