Haukeland University Hospital, Bergen

Loss of BCL-2 in the progression of oral cancer not attributed to mutations

Published in Hospital Law Weekly, January 5th, 2006

Researchers discounted mutations as the reason for loss of BCL-2 in the progression of oral cancer.

"BCL-2 and BAX are important in the regulation of apoptosis. There have been reports of loss of BCL-2 in basal cells of oral epithelial dysplasia (OED) and in oral squamous cell carcinoma (OSCC), and suppression of BAX in poorly differentiated OSCC," scientists reported in the Journal of Clinical Pathology.

"To investigate whether loss of BCL-2 in OED and OSCC, and of BAX in poorly differentiated OSCC could be attributed to BCL-2 and BAX mutations, immunohistochemistry and in situ hybridization were used to confirm BCL-2 and BAX expression. DNA...

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Source: Hospital Law Weekly (2006-01-05)

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