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Erasmus Medical Center, Rotterdam

Monkeypox virus infection is more effectively treated with antivirals than with smallpox vaccine

Published in Hospital Law Weekly, March 30th, 2006

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.

According to recent research from the Netherlands and Belgium, "There is concern that variola virus, the etiological agent of smallpox, may be used as a biological weapon. For this reason several countries are now stockpiling (vaccinia virus-based) smallpox vaccine. Although the preventive use of smallpox vaccination has been well documented, little is known about its efficacy when used after exposure to the virus."

"Here we compare the effectiveness of postexposure smallpox vaccination and antiviral treatment with either cidofovir (also called...

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