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Pediatric Cardiology

Successful Fontan circulation may be marked by high ANP levels early after surgery

Published in Hospital Law Weekly, November 16th, 2006

High levels of atrial natriuretic peptide (ANP) measured early postoperatively can be used as a marker for the successful establishment of Fontan circulation in patients with complex congenital heart defects.

Investigators in Turkey report, "Fontan operation and its modifications are used for the physiological correction of complex congenital heart malformations with functionally single ventricle. Atrial natriuretic peptide (ANP), a physiological diuretic and vasodilator that - together with the effects of cardiopulmonary bypass - plays an important role in the augmentation of capillary permeability in Fontan patients. The rise in right atrial pressure and wall stress...

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