Published in Hospital Law Weekly, November 30th, 2006
This trend article about Oregon Health & Science University, U.S., is an immediate alert from NewsRx to identify developing directions of research.
Study 1: Patients with advanced soft tissue sarcoma did not exhibit objective response to O-6-benzylguanine (O-6-BG) and carmustine (BCNU) chemotherapy.
"Tumor resistance to alkylating agents such as BCNU has been found to be associated with intracellular expression of O-6-methylguanine-DNA methyltransferase (MGMT). Administration of O-6-BG, a substrate that inactivates MGMT, may help overcome...
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Source: Hospital Law Weekly (2006-11-30)
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