Prostate Cancer

New prostate cancer study findings have been reported by researchers at Brigham and Women's Hospital, Department of Pathology

Published in Hospital Law Weekly, December 21st, 2006

Research findings, "Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer," are discussed in a new report. "Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We describe the use of a novel bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression called COPA (cancer outlier profile analysis)," investigators in the United States report.

"We demonstrate how this approach led to the identification of gene fusions of the 5'-untranslated region of TMPRSS2 (21q22.3), an androgen regulated gene, with the ETS transcription factor...

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Source: Hospital Law Weekly (2006-12-21)

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