"Pregnancy-associated plasma protein-A (PAPP-A), a metalloproteinase in the insulin-like growth factor (IGF) system, is markedly upregulated in human atherosclerotic plaque. To determine whether PAPP-A plays an active role in the development of atherosclerosis, we crossed mice lacking apolipoprotein E ( ApoE) with PAPP-A-deficient mice, generating ApoE knock-out ( KO), PAPP-A KO, wild-type (WT/WT), and ApoE/PAPP-A double KO (KO/KO) mice," scientists writing in the journal Circulation Research report.
"These mice were fed a high-fat diet starting at 7 weeks of age. Total serumcholesterol levels were elevated similarly in the ApoE KO and KO/KO mice and were...
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