Pharmacology

Research conducted at Showa University has provided new information about pharmacology

Published in Hospital Law Weekly, November 8th, 2007

"We investigated the corneal toxicity of ortho-phthataldehyde (Cidex(R)OPA, Johnson and Johnson K.K.) and its predecessor glutaraldehyde (Cidex(R), Johnson and Johnson K.K.). We made primary cultures of porcine and human corneal endothelial cells," investigators in Kanagawa, Japan report.

"Commercially available cell lines were also used including human, bovine, and rabbit corneal epithelium and human conjunctival cells. Following incubation for two days, cell survival was measured using a WST-1 assay for endothelia and a MTT assay for the other cells. Test solutions included 2.25% and 3.5% glutaraldehyde and 0.55% ortho-phthalaldehyde. Cell survival was presented as a...

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Source: Hospital Law Weekly (2007-11-08)

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