Life Sciences
Research on life sciences described by scientists at St. Jude Children's Research Hospital
Published in Hospital Law Weekly, January 17th, 2008
A report, 'Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp,' is newly published data in Molecular Cell. "To investigate the disposal of nonglycosylated BiP substrates, we used a nonsecreted kappa LC, which exists in partially (ox1) and completely (ox2) oxidized states. The ox2 form is partially reduced in order to be degraded, and only the ox1 form is ubiquitinated and associates with both Herp and Derlin-1," investigators in the United States report.
"Herp is in a complex with ubiquitinated proteins and with the 26S proteasome, suggesting that it plays a role in linking substrates with the proteasome. Overexpressed Herp...
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Source: Hospital Law Weekly (2008-01-17)
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