Mathematical Modeling
Data from St. Jude Children's Research Hospital, Department of Pharmaceutical Sciences provide new insights into mathematical modeling in children
Published in Hospital Law Weekly, February 28th, 2008
Current study results from the report, 'Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma,' have been published. "The study aims to use mathematical modeling and simulation to assess the relative contribution of topotecan systemic exposure and scheduling in the activity and myelosuppression of topotecan in pediatric patients with neuroblastoma. Pharmacokinetic and pharmacodynamic data were obtained from a phase II study for pediatric patients with high-risk neuroblastoma," investigators in the United States report.
"The topotecan dosage was individualized to attain a...
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Source: Hospital Law Weekly (2008-02-28)
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