Life Sciences

Studies from G.L. Gravina et al have provided new data on life sciences

Published in Hospital Law Weekly, June 26th, 2008

According to recent research from Coppito, Italy, "About 20-30% of hormone-independent PCa are characterized by the extensive loss of AR expression that appears to occur at the transcriptional level. Treatment of AR-negative PCa cells with demethylating agents (Aza-CR) leads to expression of AR mRNA and protein."

"Here, we investigate the effect of Aza-CR administered both acutely and chronically on AR expression, PSA expression, cell survival, and proliferation in androgen-independent/AR-negative PCa cells. We also studied whether epigenetically reactivated AR is a target for bicalutamide therapy. The in vitro effect of Aza-CR as single agent and its ability to induce...

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Source: Hospital Law Weekly (2008-06-26)

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