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HIV/AIDS

New HIV/AIDS findings from A. Alhetheel and co-authors described

Published in Hospital Law Weekly, August 14th, 2008

"Monocytes/macrophages play a major role in inflammation and pathogen clearance. However, chronic immune activation observed during HIV infection may also cause cellular dysfunction and tissue pathology," investigators in Ottawa, Canada report.

"Indeed, several defects have been reported in these cells during HIV infections. As cytokine responsiveness via the signal transducer and activator of transcription (STAT1) signaling pathway is critical for these functions, we hypothesized that its activation in monocytes from HIV-positive patients may be disrupted. To evaluate cytokine-dependent STAT signaling in monocytes from HIV-positive patients and study the biological...

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