Hemangioma

New hemangioma data have been reported by researchers at Columbus Children's Hospital

Published in Hospital Law Weekly, December 25th, 2008

According to a study from the United States, "Infantile hemangiomas are localized and rapidly growing regions of disorganized angiogenesis. We show that expression of vascular endothelial growth factor receptor-1 (VEGFR1) in hemangioma endothelial cells (hemECs) and hemangioma tissue is markedly reduced compared to controls."

"Low VEGFR1 expression in hemECs results in VEGF-dependent activation of VEGFR2 and downstream signaling pathways. In hemECs, transcription of the gene encoding VEGFR1 (FLT1) is dependent on nuclear factor of activated T cells ( NFAT). Low VEGFR1 expression in hemECs is caused by reduced activity of a pathway involving beta 1 integrin, the...

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Source: Hospital Law Weekly (2008-12-25)

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