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Enzyme Research

Reports from E. Roztocil and colleagues advance knowledge in enzyme research

Published in Hospital Law Weekly, February 12th, 2009

According to recent research from the United States, "Sphingosine-1-phosphate (S-1-P) is a bioactive sphingolipid released front activated platelets that, stimulates migration of vascular smooth muscle cells (VSMC) in vitro. S-1-P will activate akt, which can regulate multiple cellular functions including cell migration."

"Akt activation is downstream of phosphatidylinositol 3'-kinase (PI3-K) and phosphoinositide-dependent protein kinase-1 (PDK1). The objective of this study was to examine the regulation of akt signaling during smooth muscle cell (SMC) migration in response to S-1-P Methods. Murine arterial SMC were cultured in vitro. Linear wound and microchemotaxis...

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