Breast Cancer

Findings in breast cancer reported from Columbus Children's Hospital

Published in Hospital Law Weekly, May 14th, 2009

According to a study from the United States, "Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, and we identify the mechanisms underlying this function. We first found that Lcn2 levels were consistently associated with invasive breast cancer in human tissue and urine samples."

"To investigate the function of Lcn2 in breast cancer progression, Lcn2 was overexpressed in human breast cancer cells and was found to up-regulate mesenchymal markers, including vimentin and fibronectin, down-regulate the epithelial marker E-cadherin, and significantly increase cell motility and invasiveness. These changes in marker expression and cell motility are...

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Source: Hospital Law Weekly (2009-05-14)

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