Apoptosis

Research from A. Alisi et al broadens understanding of apoptosis

Published in Hospital Law Weekly, October 15th, 2009

According to recent research from Rome, Italy, "Oxidative stress influences a variety of regulatory proteins, including nuclear factor-kappa B (NF-kappa B). NF-kappa B is critical for maintaining the proliferation/apoptosis balance in hepatocytes."

"In this study we investigated the causal links between glutathione, NF-kappa B and hepatocyte damage. HepG2 and 3B cells were exposed to different doses of H2O2 or N-acetyl-cysteine (NAC) and the proliferation/apoptosis rate, glutathione forms, and p65NF-kappa B glutathionylation and activity were analysed. Our results demonstrate that H2O2 stopped proliferative response at low doses, but induced apoptosis only at high...

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Source: Hospital Law Weekly (2009-10-15)

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