Epstein-Barr Virus
Research in the area of Epstein-Barr virus reported from Brigham and Women's Hospital
Published in Hospital Law Weekly, January 7th, 2010
According to recent research from the United States, "B lymphocytes converted into lymphoblastoid cell lines (LCLs) by an Epstein-Barr virus that expresses a conditional EBNA3C require complementation with EBNA3C for growth under nonpermissive conditions. Complementation with relatively large EBNA3C deletion mutants identified amino acids (aa) 1 to 506 ( which includes the RBP-J kappa/CSL [RBP-J kappa] binding domain) and 733 to 909 to be essential for LCL growth, aa 728 to 732 and 910 to 992 to be important for full wild-type (wt) growth, and only aa 507 to 727 to be unimportant (S. Maruo, Y. Wu, T. Ito, T. Kanda, E. D. Kieff, and K. Takada, Proc. Natl. Acad. Sci. USA 106:4419-4424,...
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Source: Hospital Law Weekly (2010-01-07)
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