Gladstone Institute of Neurological Disease

Study reveals how genetic factor may increase risk for AD

Published in Hospital and Nursing Home Week, April 15th, 2004

Researchers at the Gladstone Institute of Neurological Disease have identified processes that may explain how a key protein, apolipoprotein E4 (apoE4), contributes to the development of Alzheimer disease.

Their findings, described in the Journal of Neuroscience, include identifying where in the brain apoE4 is broken down into toxic fragments that can impair the function and survival of nerve cells. Results of their study may point the way to a new therapeutic strategy for the prevention and treatment of Alzheimer disease.

ApoE4 is the best-known genetic risk factor for Alzheimer disease, but, until now, the mechanism by which it increases that...

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Source: Hospital and Nursing Home Week (2004-04-15)

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