Univ. of Klinikum Carl Gustav Carus

Effect of nonselective NOS inhibition in critically ill patients reported

Published in Hospital and Nursing Home Week, September 30th, 2004

Scientists have reported evidence that points to a possible cause for the deleterious effect of early nonselective NOS inhibition in critically ill patients.

According to a study from Germany, "Nitric oxide synthase (NOS) inhibitors are considered promising as a therapeutic option in severe septic shock. The aim of this study was to investigate the effects of N-omega-nitro-L-arginine methyl ester (L-NAME) application on neutrophil (PMN) respiratory burst, phagocytosis, and elimination of Escherichia coli from blood and tissue in rabbits. Twenty-eight female chinchilla rabbits were randomized to a treatment and control group."

"To quantify the...

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Source: Hospital and Nursing Home Week (2004-09-30)

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