Hannover Medical School
Genetically modified Schwann cells help dopaminergic micrografts survive
Published in Hospital and Nursing Home Week, October 28th, 2004
"Dopaminergic (DA) micrografts were co-transplanted with Schwann cells (SC) overexpressing 18 kDa and 21/23 kDa fibroblast growth factor (FGF)-2 into the caudate-putamen unit (CPu) of unilaterally 6-hydroxydopamine-lesioned rats. We report here that SC engineered to overexpress FGF-2 promoted DA-graft-induced restoration, whether co-transplanted at the same site or grafted at a second more distant site within the Cpu," scientists in Germany report.
"In addition, the 21/23 kDa FGF-2 isoforms resulted in a significantly better reinnervation and survival of dopaminergic...
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